Abstract Finasteride is a 5α-reductase enzyme inhibitor that has been approved for the treatment of male androgenic alopecia since 1997. Over time, it has been considered a safe and well-tolerated drug with rare and reversible side effects. Recently there have been reports of adverse drug-related reactions that persisted for at least three months after discontinuation of this drug, and the term post-finasteride syndrome arose. It includes persistent sexual, neuropsychiatric, and physical symptoms. Studies to date cannot refute or confirm this syndrome as a nosological entity. If it actually exists, it seems to occur in susceptible people, even if exposed to small doses and for short periods, and symptoms may persist for long periods. Based on currently available data, the use of 5α-reductase inhibitors in patients with a history of depression, sexual dysfunction, or infertility should be carefully and individually assessed.

OBJETIVO: O aumento da população idosa no Brasil justifica a necessidade de avaliar os aspectos que podem interferir na qualidade de vida de aposentados. MÉTODOS: A versão brasileira do questionário SF-36 foi aplicada em 87 aposentados para avaliação da qualidade de vida. Os resultados obtidos foram associados às características demográficas, socioeconômicas, condições de saúde e estilo de vida e foram estudados por meio de análise uni e multivariada. RESULTADOS: A idade média foi de 57,3 anos (desvio-padrão de 8,9 anos) e tempo médio de aposentadoria foi de 7,1 anos. A aposentadoria foi por invalidez em 55,2% da amostra e 23,4% dos aposentados trabalhavam no momento da pesquisa. Os fumantes somaram 11,5% e 5,7% eram dependentes de álcool. A depressão e hipertensão arterial sistêmica foram as doenças mais prevalentes, e 56,3% dos aposentados praticavam algum tipo de atividade física regularmente. Após a análise multivariada, evidenciou-se melhor qualidade de vida apenas nos aposentados que praticavam atividade física regular ou que tinham alguma atividade de trabalho no momento da pesquisa. CONCLUSÃO: O questionário SF-36 foi um instrumento adequado, de aplicação relativamente rápida e de fácil uso para avaliação da qualidade de vida em aposentados. A qualidade de vida na amostra estudada foi associada ao estilo de vida dos pacientes e aponta para a necessidade de ações que contribuam de forma positiva para melhorar o estilo de vida nesta nova fase da vida.

OBJECTIVE: Increase of the elderly in the Brazilian population demands assessment of aspects that interfere with the retirees' quality of life. METHODS: The Brazilian version of SF-36 questionnaire was applied to 87 retirees at their homes. Data on quality of life was associated with demographic data, socioeconomic status, health conditions and life style. Statistical analysis of data was performed using single-variable and multivariate analysis. RESULTS: The mean age was 57.3 years (standard deviation 8.9 years) and the mean retirement time was 7.1 years. Fifty-five percent were early retirements due to disability and 23.4% of those queried were still working when research was carried out. Smokers were 11.5% and 5.7 % were diagnosed as alcohol dependent by CAGE criteria. Depression and arterial systemic hypertension were the most prevalent conditions and 56.3% of the retirees practiced regular physical activity. Multivariate analysis disclosed that regular physical activity and post-retirement occupation were the only variables associated with improved quality of life. CONCLUSION: The SF-36 questionnaire was a suitable instrument, relatively quick and easy to use. The quality of life was associated with life style, as indicated by the practice of physical activities and post-retirement occupation. Actions are needed to enable retirees to improve their life style after retirement.